Isotopically Labeled Compounds
Medchemexpress LLC Cycloguanil-d6 (chlorguanide triazine-d6) | 516-21-2 | 98.0% | 1 MG
Cycloguanil-d6 is a deuterium-labeled version of Cycloguanil, a dihydrofolate reductase (DHFR) inhibitor. It disrupts the folate metabolic pathway, affecting nucleotide synthesis and DNA replication. This compound inhibits DHFR in Plasmodium, useful in malaria research, and also in human cancer cells, demonstrating anticancer properties. Stable heavy isotopes are incorporated for use as tracers in drug development.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Inhibits dihydrofolate reductase (DHFR).
- Disrupts the folate metabolic pathway.
- Affects nucleotide synthesis and DNA replication.
- Useful in malaria research.
- Demonstrates anticancer properties.
Medchemexpress LLC Maprotiline-d5 hydrochloride | 1794942-12-3 | 1 MG
Maprotiline-d5 hydrochloride is a deuterium-labeled version of Maprotiline hydrochloride, functioning as a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant. This compound is suitable for various quantitative analyses due to its stable heavy isotopes.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes for drug development tracing
- Potential to affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Tetrahydrozoline-d4 hydrochloride | 1246814-66-3 | 99.8% | 1 MG
Tetrahydrozoline-d4 (hydrochloride) is a deuterium-labeled version of Tetrahydrozoline hydrochloride. Tetrahydrozoline hydrochloride (Tetryzoline hydrochloride) is an imidazoline derivative and an α-adrenergic agonist that induces vasoconstriction. It is commonly used in research related to nasal and conjunctival congestion.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes are incorporated into drug molecules for quantitation during drug development.
- Deuteration may affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Pacritinib-d4 | 476.60 | 5 MG
Pacritinib-d4 (SB1518-d4) is the deuterium labeled Pacritinib. It is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). This compound also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). Stable heavy isotopes have been incorporated into drug molecules, primarily as tracers for quantitation during the drug development process. Deuteration has garnered attention due to its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled compound
- Potent inhibitor of wild-type JAK2 and JAK2V617F mutant
- Inhibits FLT3 and its mutant FLT3D835Y
- Used as a tracer for quantitation during drug development
- Potential to affect pharmacokinetic and metabolic profiles
Medchemexpress LLC Caspofungin-d4 | 1131958-73-0 | 1097.34 | 500 UG
Caspofungin-d4 is a deuterium-labeled version of Caspofungin, a potent antifungal agent. It works by inhibiting the synthesis of β-(l,3)-D-glucan, a crucial component of the fungal cell wall. This compound is intended for research use only and is not for patient administration. Deuterium substitution can influence the pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled.
- Potent antifungal agent.
- Inhibits synthesis of fungal cell wall component β-(l,3)-D-glucan.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC D-Glucose-d12-1 | 89798-27-6 | 99.4% | 5 MG
D-Glucose-d12-1 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. It is a carbohydrate sweetener and a critical component of general metabolism, serving as a critical signaling molecule in relation to both cellular metabolic status and biotic and abiotic stress response.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Sulfamethoxazole-d4 | 1020719-86-1 | 99.3% | 1 MG
Sulfamethoxazole-d4 is a deuterium-labeled sulfonamide antibiotic with broad antibacterial activity. It functions by inhibiting bacterial folate metabolism through competition with 4-Aminobenzoic acid (PABA) for dihydropteroate synthetase and dihydropteroate reductase. This compound is suitable for studies of urinary tract infections (UTIs), prostatitis, and bronchitis.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis
- Deuteration may affect pharmacokinetic and metabolic profiles of drugs
- Available in solid form
Medchemexpress LLC Sulfamethazine-d4 (sulfadimidine-d4) | 1020719-82-7 | MFCD03701230 | 99.9% | 282.35 g/mol | C12H10D4N4O2S | 10 MG
Sulfamethazine-d4 is a deuterium-labeled analogue of sulfamethazine supplied as a solid for analytical and research use. It is used primarily as an isotopically labeled internal standard or tracer for quantitative analyses by LC-MS, GC-MS, and NMR. The material is provided at high purity with defined storage recommendations to ensure stability in analytical workflows.
- Deuterium-labeled internal standard for quantitative assays.
- High purity suitable for reference and analytical use.
- White to off-white solid form, stable when stored at -20°C.
- Compatible with LC-MS, GC-MS, and NMR methods.
- Includes common synonyms for easy cross-referencing.
Medchemexpress LLC Sorafenib-13C,d3 | 1210608-86-8 | 98.4% | 468.84 g·mol⁻¹ | C2013CH13D3ClF3N4O3 | 1 MG
Sorafenib-13C,d3 is a stable isotope-labeled analogue of the multikinase inhibitor sorafenib, incorporating 13C and three deuterium atoms for use in analytical and tracer research. It is supplied as a high-purity research reagent for laboratory methods such as LC-MS quantitation and metabolic profiling; not for human or veterinary use.
- Stable isotope labeling (13C and d3) for tracer and mass spectrometry studies.
- High purity (98.4%) suitable for analytical applications.
- Molecular weight 468.84 g·mol⁻¹.
- Optimized for LC-MS quantitation and metabolic profiling.
- Available in small, research-scale quantities (e.g., 1 mg vials).
- For research use only; not intended for clinical use.
Cayman Chemical ResolvIn D3 50ug
A DHA-derived product first identified in mouse inflammatory exudates; reduces neutrophil infiltration in vivo in both mouse peritonitis and dermal inflammation; enhances macrophage phagocytosis and efferocytosis
Cambridge Isotope Laboratories GLYCAN-O27-13C-GAL6 (GALACTOSE-13C6, 99%), 500 PMOL
GLYCAN-O27-13C-GAL6 (GALACTOSE-13C6, 99%), 500 PMOL
Medchemexpress LLC Leukotriene B4-d4 10ug | 124629-74-9 | 10UG
Leukotriene B4-d4 is the deuterium labeled Leukotriene B4 Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1 [2 [3
Cambridge Isotope Laboratories 2 3 3 4 4 5 5 6-OctaBDE (BDE-205) (13C12 99%) 50 ug/mL in nonane 1 2 mL
2 3 3 4 4 5 5 6-OctaBDE (BDE-205) (13C12 99%) 50 ug/mL in nonane 1 2 mL
Medchemexpress LLC Propranolol-d7 hydrochloride | 1613439-56-7 | MFCD11983489 | 98.5% | 10 MG
Propranolol-d7 hydrochloride is a deuterium-labeled analog of propranolol supplied as a solid hydrochloride salt. It is intended for use as a labeled reference standard and internal standard in LC-MS/MS and bioanalytical assays for quantitation and pharmacokinetic studies.
- Deuterium-labeled internal standard for mass spectrometry.
- Hydrochloride salt, solid form for stable storage.
- High isotopic labeling and ≥98.5% chemical purity.
- Suitable for LC-MS/MS quantitation and pharmacokinetic studies.
- Provided in small reference quantities for analytical workflows.
Cambridge Isotope Laboratories Taurohyodeoxycholic Acid Sodium Salt (2 2 3 3-D4 98%) CP 95% 1 mg
Taurohyodeoxycholic Acid Sodium Salt (2 2 3 3-D4 98%) CP 95% 1 mg